Kyle Manzardo hit a grand slam after a successful challenge on a hit-by-pitch call, leading the Cleveland Guardians to a 6-5 victory over the Cincinnati Reds on Tuesday in the first game of a doubleheader. Manzardo initially appeared to be hit by a pitch, but the umpire ruled otherwise. After review, the call was overturned, giving Manzardo another chance, which he capitalized on with a bases-loaded home run. Later, Chase DeLauter scored the go-ahead run on a sacrifice bunt in the eighth inning, snapping the Guardians' five-game losing streak. José Ramírez had two hits and stole two bases in the fifth inning before scoring the tying run. Sal Stewart drove in three runs for the Reds, including a two-run double that gave Cincinnati a 5-4 lead during a four-run fourth inning.